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The EMBO Journal publishes papers describing original research of broad general interest in molecular and cell biology - a particular emphasis is placed on molecular mechanism and physiological relevance. The journal encourages and publishes articles that report novel findings of wide biological significance in the areas of: Ageing Autophagy Cancer Cell Adhesion, Polarity & Cytoskeleton Cell Cycle Cell Death Chromatin, Epigenetics & Genomics Developmental Biology DNA Replication, Repair & Recombination Ecology & Evolution Immunology Membrane & Intracellular Transport Metabolism Microbiology, Virology & Host Pathogen Interaction Molecular Biology of Disease Neuroscience Plant Biology Post-translational Modifications, Proteolysis & Proteomics RNA Biology Signal Transduction Stem Cells Structural Biology Systems, Chemical & Computational Biology Transcription Protein Biosynthesis & Quality Control Vascular Biology